Project Reports

Molly Durawa

Worked with Megan. RNA Binding Proteins (RBPs). Different isoforms of a given RBP may have different functions. Broad goal: How alternative splicing of RBPs affect their downstream functions?

RBM10 is a splicing factor with multiple isoforms. The isoforms are consistently expressed and differ in their functional domains.

Jiayu Su

Spatial Isoform Statistical Modeling. (Splisosm).

Characterizing the spatial splicing landscape using Splisosm.

GLMM. Multinomial model. Hilbert-Schmidt Independence Criterion. Spatial Variation (SV) and Differential Usage (DU) tests. The HSIC-based DU test does not account for spatial randomness.