2024-06-26

Presentation by Aline Real

Meta-analysis approach to discover sQTLs in the BigBrain dataset

sQTLs are enriched among Alzheimer’s disease GWAS and Parkinson’s disease GWAS.

Use mmQTL for analysis. Biao Zang, Nature Genetics 2022. Within each brain region using a linear mixed model to account for population stratification. Random effects meta-analysis.